Vayne Runes explained
There's one set of runes for Vayne on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Vayne rune paths on the position 
Adc are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 57%. Besides picking runes on Vayne you should learn how to play Vayne and if you are interested in pro matches take a look on how a pro builds Vayne. If you want to discuss 
Vayne then you should visit the champion subreddit.
Vayne runes from primary path
Precision improves attack and sustained damage on Vayne troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Press the Attack is the best keystone rune to run on Vayne. Vayne has a very easy time activating this rune with basic attacks which synergises well with Press the Attack’s damage increase once activated. Other primary runes on Vayne are 
Presence of Mind, 
Legend: Alacrity and 
Cut Down.
Presence of Mind helps Vayne with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Vayne. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Vayne runes from secondary path
When it comes to your secondary path, most Vayne players prefer to go with Domination. Domination improves burst damage and assassination tools on Vayne. On the Domination path, the best runes for Vayne are 
Sudden Impact and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Vayne with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Treasure Hunter is the final rune of the Domination path. This rune gives Vayne additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Vayne will gain an additional 70 gold for the first takedown. Vayne acquires Bounty Hunter Stacks, which Vayne may use to get more takedowns. This rune's power will grow tremendously, and Vayne will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Vayne will get an additional twenty gold.
FAQ for Vayne Runes
Which is the best keystone rune on Vayne?
The best keystone rune on Vayne is Press the Attack. This Vayne runes setup is then referred as Vayne Press the Attack.
What runes does Vayne use?
Runes from the paths Precision and Domination are the most used runes on Vayne. For the exact pick rates of Vayne runes used, you have to study the rune distribution presented.