How to counter Vayne
Let us take a look on how to beat Vayne. We will look at champions who are strong against Vayne and who are weak against Vayne. Use win rate, gold difference and creep score difference at minute 10 to find the best 
Adc champion who counters Vayne. You can already win in champion select with the right counters for Vayne. If you want to know how to counter Vayne then you need to take into account the best picks vs Vayne and the worst picks vs Vayne. This Vayne counter data is based on matches played by Pros on patch 14.21 and previous ones. It is important to see whether Pros counter picked Vayne or whether they played as Vayne.
Champions used by Pros to counter pick Vayne
Looking at the matches from Pros (see table Pros counter picked Vayne) we can see that they picked 
Kai'Sa most often to counter pick Vayne. The matchup Kai'Sa vs Vayne occured 22 times. Vayne has 16 wins and 6 losses in this matchup. Learn how to counter pick Kai'Sa to get another perspective on the data.
Lane outcome for Vayne
When looking at Vayne counters you will notice that win rates alone are not conclusional. Therefore we provide an overview (see table Lane Outcome) where you can see the lane outcome of Pros who played Vayne. The lane outcome of Vayne consists of three outcomes: Win, Loss or Draw. Let's take a look of Vayne lane and match outcome for specific matchups. Considering the lane outcome and the match outcome of a specific matchup, might enable you to find the right counter for Vayne.
Conclusion
Analyze the available data and learn how to beat Vayne. To master Vayne take also a look on Vayne builds and runes for Vayne. Good luck, Summoner!