Zoe Runes explained
There's one set of runes for Zoe on patch 14.20 that is the clear favorite for LoL players and pros alike. The best Zoe rune paths on the position 
Support are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 62%. Besides picking runes on Zoe you should learn how to play Zoe and if you are interested in pro matches take a look on how a pro builds Zoe. If you want to discuss 
Zoe then you should visit the champion subreddit.
Zoe runes from primary path
Domination improves burst damage and assassination tools on Zoe. Most of high elo players – and our LoL pros in the the major regions – have agreed that Dark Harvest is the best keystone rune to run on Zoe. This keystone rune gives you additional damage throughout the match. Other primary runes on Zoe are Sudden Impact, Eyeball Collection and Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Zoe with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Zoe additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Zoe will gain an additional 70 gold for the first takedown. Zoe acquires Bounty Hunter Stacks, which Zoe may use to get more takedowns. This rune's power will grow tremendously, and Zoe will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Zoe will get an additional twenty gold.
Zoe runes from secondary path
When it comes to your secondary path, most Zoe players prefer to go with Sorcery. Sorcery empoweres abilities of Zoe and increases the available champion resources. On the Sorcery path, the best runes for Zoe are 
Gathering Storm and 
Scorch.
Gathering Storm increases your late game power. Scorch increases your control in the early game.
FAQ for Zoe Runes
Which is the best keystone rune on Zoe?
The best keystone rune on Zoe is Dark Harvest. This Zoe runes setup is then referred as Zoe Dark Harvest.
What runes does Zoe use?
Runes from the paths Domination and Sorcery are the most used runes on Zoe. For the exact pick rates of Zoe runes used, you have to study the rune distribution presented.