Yorick Runes explained
There's one set of runes for Yorick on patch 15.4 that is the clear favorite for LoL players and pros alike. The best Yorick rune paths on the position 
Top are 
Domination as the primary path and Precision as the secondary path with a pick rate of 63%. Besides picking runes on Yorick you should learn how to play Yorick and if you are interested in pro matches take a look on how a pro builds Yorick. If you want to discuss 
Yorick then you should visit the champion subreddit.
Yorick runes from primary path
Domination improves burst damage and assassination tools on Yorick. Most of high elo players – and our LoL pros in the the major regions – have agreed that Electrocute is the best keystone rune to run on Yorick. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Yorick are Taste of Blood, Deep Ward and Relentless Hunter.
Taste of Blood heals Yorick as soon as you damage an opposing champion. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Yorick runes from secondary path
When it comes to your secondary path, most Yorick players prefer to go with Precision. Precision improves attack and sustained damage on Yorick troughout the match. On the Precision path, the best runes for Yorick are Legend: Bloodline and Presence of Mind.
Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. Presence of Mind helps Yorick with the mana problems by restoring missing mana, if a champion is killed.
FAQ for Yorick Runes
Which is the best keystone rune on Yorick?
The best keystone rune on Yorick is Electrocute. This Yorick runes setup is then referred as Yorick Electrocute.
What runes does Yorick use?
Runes from the paths Domination and Precision are the most used runes on Yorick. For the exact pick rates of Yorick runes used, you have to study the rune distribution presented.