Yone Runes explained
There's one set of runes for Yone on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Yone rune paths on the position 
Mid are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 99%. Besides picking runes on Yone you should learn how to play Yone and if you are interested in pro matches take a look on how a pro builds Yone. If you want to discuss 
Yone then you should visit the champion subreddit.
Yone runes from primary path
Precision improves attack and sustained damage on Yone troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Yone. This keystone rune gives Yone a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Yone are 
Triumph, 
Legend: Alacrity and 
Last Stand.
Triumph restores on Yone a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Yone. With Last Stand you deal more damage while you are at low health.
Yone runes from secondary path
When it comes to your secondary path, most Yone players prefer to go with Resolve. Resolve empowers the survivability of Yone and increases the tankiness. On the Resolve path, the best runes for Yone are 
Overgrowth and 
Second Wind.
Overgrowth increases your maximum amount of health. Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion.
FAQ for Yone Runes
Which is the best keystone rune on Yone?
The best keystone rune on Yone is Lethal Tempo. This Yone runes setup is then referred as Yone Lethal Tempo.
What runes does Yone use?
Runes from the paths Precision and Resolve are the most used runes on Yone. For the exact pick rates of Yone runes used, you have to study the rune distribution presented.