Vladimir Runes explained
There's one set of runes for Vladimir on patch 15.3 that is the clear favorite for LoL players and pros alike. The best Vladimir rune paths on the position 
Mid are 
Sorcery as the primary path and Resolve as the secondary path with a pick rate of 48%. Besides picking runes on Vladimir you should learn how to play Vladimir and if you are interested in pro matches take a look on how a pro builds Vladimir. If you want to discuss 
Vladimir then you should visit the champion subreddit.
Vladimir runes from primary path
Sorcery empoweres abilities of Vladimir and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that Summon Aery is the best keystone rune to run on Vladimir. This keystone rune adds more poke damage to your abilities. And additionally grants an extra shield, whenever Vladimir empowers or protects an ally with abilities. Other primary runes on Vladimir are Nimbus Cloak, Transcendence and Scorch.
Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, Smite. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Vladimir runes from secondary path
When it comes to your secondary path, most Vladimir players prefer to go with Resolve. Resolve empowers the survivability of Vladimir and increases the tankiness. On the Resolve path, the best runes for Vladimir are Second Wind and Revitalize.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Revitalize inceases heals and shields you distribute or receive.
FAQ for Vladimir Runes
Which is the best keystone rune on Vladimir?
The best keystone rune on Vladimir is Summon Aery. This Vladimir runes setup is then referred as Vladimir Summon Aery.
What runes does Vladimir use?
Runes from the paths Sorcery and Resolve are the most used runes on Vladimir. For the exact pick rates of Vladimir runes used, you have to study the rune distribution presented.