Twitch Runes explained
There's one set of runes for Twitch on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Twitch rune paths on the position 
Adc are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 73%. Besides picking runes on Twitch you should learn how to play Twitch and if you are interested in pro matches take a look on how a pro builds Twitch. If you want to discuss 
Twitch then you should visit the champion subreddit.
Twitch runes from primary path
Precision improves attack and sustained damage on Twitch troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Press the Attack is the best keystone rune to run on Twitch. Twitch has a very easy time activating this rune with basic attacks which synergises well with Press the Attack’s damage increase once activated. Other primary runes on Twitch are 
Presence of Mind, 
Legend: Alacrity and 
Cut Down.
Presence of Mind helps Twitch with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Twitch. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Twitch runes from secondary path
When it comes to your secondary path, most Twitch players prefer to go with Domination. Domination improves burst damage and assassination tools on Twitch. On the Domination path, the best runes for Twitch are 
Sudden Impact and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Twitch with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Treasure Hunter is the final rune of the Domination path. This rune gives Twitch additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Twitch will gain an additional 70 gold for the first takedown. Twitch acquires Bounty Hunter Stacks, which Twitch may use to get more takedowns. This rune's power will grow tremendously, and Twitch will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Twitch will get an additional twenty gold.
FAQ for Twitch Runes
Which is the best keystone rune on Twitch?
The best keystone rune on Twitch is Press the Attack. This Twitch runes setup is then referred as Twitch Press the Attack.
What runes does Twitch use?
Runes from the paths Precision and Domination are the most used runes on Twitch. For the exact pick rates of Twitch runes used, you have to study the rune distribution presented.