Twisted Fate Runes explained
There's one set of runes for Twisted Fate on patch 14.23 that is the clear favorite for LoL players and pros alike. The best Twisted Fate rune paths on the position 
Support are 
Inspiration as the primary path and Sorcery as the secondary path with a pick rate of 48%. Besides picking runes on Twisted Fate you should learn how to play Twisted Fate and if you are interested in pro matches take a look on how a pro builds Twisted Fate. If you want to discuss 
Twisted Fate then you should visit the champion subreddit.
Twisted Fate runes from primary path
Inspiration opens creative opportunities on Twisted Fate troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that Unsealed Spellbook is the best keystone rune to run on Twisted Fate. This keystone rune allows Twisted Fate to create a one-time use summoner spell. The new summoner spell replaces one of their current summoner spells and remains available until it is used or replaced. Unsealed Spellbook has some unique rules in that a particular summoner spell cannot be selected again until three other unique spells have been taken. LoL pro players will often use Unsealed Spellbook to aid them in their current or upcoming situation. Are you about to fight the last dragon for a soul buff? Due to Unsealed Spellbook, Twisted Fate can choose Smite to help their jungler secure the dragon for the team. There are numberless circumstances where a particular summoner spell can turn the game on its head, and that's where Unsealed Spellbook shines the most. Other primary runes on Twisted Fate are Magical Footwear, Biscuit Delivery and Cosmic Insight.
Magical Footwear allows Twisted Fate to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Twisted Fate runes from secondary path
When it comes to your secondary path, most Twisted Fate players prefer to go with Sorcery. Sorcery empoweres abilities of Twisted Fate and increases the available champion resources. On the Sorcery path, the best runes for TwistedFate are Celerity and Nimbus Cloak.
Celerity boosts all movement speed bonuses to Twisted Fate. Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, Smite.
FAQ for Twisted Fate Runes
Which is the best keystone rune on Twisted Fate?
The best keystone rune on Twisted Fate is Unsealed Spellbook. This Twisted Fate runes setup is then referred as Twisted Fate Unsealed Spellbook.
What runes does Twisted Fate use?
Runes from the paths Inspiration and Sorcery are the most used runes on Twisted Fate. For the exact pick rates of Twisted Fate runes used, you have to study the rune distribution presented.