Tristana Runes explained
There's one set of runes for Tristana on patch 15.3 that is the clear favorite for LoL players and pros alike. The best Tristana rune paths on the position 
Adc are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 50%. Besides picking runes on Tristana you should learn how to play Tristana and if you are interested in pro matches take a look on how a pro builds Tristana. If you want to discuss 
Tristana then you should visit the champion subreddit.
Tristana runes from primary path
Precision improves attack and sustained damage on Tristana troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Tristana. This keystone rune gives Tristana a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Tristana are 
Triumph, 
Legend: Bloodline and 
Cut Down.
Triumph restores on Tristana a part of missing health and award bonus gold, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Tristana runes from secondary path
When it comes to your secondary path, most Tristana players prefer to go with Inspiration. Inspiration opens creative opportunities on Tristana troughout the match. On the Inspiration path, the best runes for Tristana are 
Biscuit Delivery and 
Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Tristana Runes
Which is the best keystone rune on Tristana?
The best keystone rune on Tristana is Lethal Tempo. This Tristana runes setup is then referred as Tristana Lethal Tempo.
What runes does Tristana use?
Runes from the paths Precision and Inspiration are the most used runes on Tristana. For the exact pick rates of Tristana runes used, you have to study the rune distribution presented.