Tristana Runes explained
There's one set of runes for Tristana on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Tristana rune paths on the position 
Adc are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 70%. Besides picking runes on Tristana you should learn how to play Tristana and if you are interested in pro matches take a look on how a pro builds Tristana. If you want to discuss 
Tristana then you should visit the champion subreddit.
Tristana runes from primary path
Precision improves attack and sustained damage on Tristana troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Press the Attack is the best keystone rune to run on Tristana. Tristana has a very easy time activating this rune with basic attacks which synergises well with Press the Attack’s damage increase once activated. Other primary runes on Tristana are 
Presence of Mind, 
Legend: Bloodline and 
Cut Down.
Presence of Mind helps Tristana with the mana problems by restoring missing mana, if a champion is killed. Legend: Bloodline gives life steal, which aids in winning damage trades and fights in the later stages of the match. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Tristana runes from secondary path
When it comes to your secondary path, most Tristana players prefer to go with Inspiration. Inspiration opens creative opportunities on Tristana troughout the match. On the Inspiration path, the best runes for Tristana are 
Biscuit Delivery and 
Magical Footwear.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Magical Footwear allows Tristana to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Tristana Runes
Which is the best keystone rune on Tristana?
The best keystone rune on Tristana is Press the Attack. This Tristana runes setup is then referred as Tristana Press the Attack.
What runes does Tristana use?
Runes from the paths Precision and Inspiration are the most used runes on Tristana. For the exact pick rates of Tristana runes used, you have to study the rune distribution presented.