Sylas Runes explained
There's one set of runes for Sylas on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Sylas rune paths on the position 
Mid are 
Inspiration as the primary path and 
Resolve as the secondary path with a pick rate of 71%. Besides picking runes on Sylas you should learn how to play Sylas and if you are interested in pro matches take a look on how a pro builds Sylas. If you want to discuss 
Sylas then you should visit the champion subreddit.
Sylas runes from primary path
Inspiration opens creative opportunities on Sylas troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Sylas. Other primary runes on Sylas are 
Magical Footwear, 
Biscuit Delivery and 
Cosmic Insight.
Magical Footwear allows Sylas to focus on those essential core items without the need to spend the additional 300 gold on boots. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Sylas runes from secondary path
When it comes to your secondary path, most Sylas players prefer to go with Resolve. Resolve empowers the survivability of Sylas and increases the tankiness. On the Resolve path, the best runes for Sylas are Second Wind and Unflinching.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Unflinching inceases Sylas tenacity based on your missing health.
FAQ for Sylas Runes
Which is the best keystone rune on Sylas?
The best keystone rune on Sylas is First Strike. This Sylas runes setup is then referred as Sylas First Strike.
What runes does Sylas use?
Runes from the paths Inspiration and Resolve are the most used runes on Sylas. For the exact pick rates of Sylas runes used, you have to study the rune distribution presented.