Shaco Runes explained
There's one set of runes for Shaco on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Shaco rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 59%. Besides picking runes on Shaco you should learn how to play Shaco and if you are interested in pro matches take a look on how a pro builds Shaco. If you want to discuss 
Shaco then you should visit the champion subreddit.
Shaco runes from primary path
Domination improves burst damage and assassination tools on Shaco. Most of high elo players – and our LoL pros in the the major regions – have agreed that Hail of Blades is the best keystone rune to run on Shaco. This keystone rune helps you to win short damage trades in your lane by increasing your attackspeed at the beginning of a fight. Other primary runes on Shaco are Sudden Impact, Eyeball Collection and Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Shaco with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Shaco runes from secondary path
When it comes to your secondary path, most Shaco players prefer to go with Inspiration. Inspiration opens creative opportunities on Shaco troughout the match. On the Inspiration path, the best runes for Shaco are 
Magical Footwear and 
Cosmic Insight.
Magical Footwear allows Shaco to focus on those essential core items without the need to spend the additional 300 gold on boots. Cosmic Insight grants summoner spell and item haste.
FAQ for Shaco Runes
Which is the best keystone rune on Shaco?
The best keystone rune on Shaco is Hail of Blades. This Shaco runes setup is then referred as Shaco Hail of Blades.
What runes does Shaco use?
Runes from the paths Domination and Inspiration are the most used runes on Shaco. For the exact pick rates of Shaco runes used, you have to study the rune distribution presented.