Seraphine Runes explained
There's one set of runes for Seraphine on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Seraphine rune paths on the position 
Support are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 42%. Besides picking runes on Seraphine you should learn how to play Seraphine and if you are interested in pro matches take a look on how a pro builds Seraphine. If you want to discuss 
Seraphine then you should visit the champion subreddit.
Seraphine runes from primary path
Sorcery empoweres abilities of Seraphine and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Summon Aery is the best keystone rune to run on Seraphine. This keystone rune adds more poke damage to your abilities. And additionally grants an extra shield, whenever Seraphine empowers or protects an ally with abilities. Other primary runes on Seraphine are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Seraphine runes from secondary path
When it comes to your secondary path, most Seraphine players prefer to go with Inspiration. Inspiration opens creative opportunities on Seraphine troughout the match. On the Inspiration path, the best runes for Seraphine are 
Cosmic Insight and 
Biscuit Delivery.
Cosmic Insight grants summoner spell and item haste. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Seraphine Runes
Which is the best keystone rune on Seraphine?
The best keystone rune on Seraphine is Summon Aery. This Seraphine runes setup is then referred as Seraphine Summon Aery.
What runes does Seraphine use?
Runes from the paths Sorcery and Inspiration are the most used runes on Seraphine. For the exact pick rates of Seraphine runes used, you have to study the rune distribution presented.