Sejuani Runes explained
There's one set of runes for Sejuani on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Sejuani rune paths on the position 
Jungle are 
Resolve as the primary path and 
Domination as the secondary path with a pick rate of 44%. Besides picking runes on Sejuani you should learn how to play Sejuani and if you are interested in pro matches take a look on how a pro builds Sejuani. If you want to discuss 
Sejuani then you should visit the champion subreddit.
Sejuani runes from primary path
Resolve empowers the survivability of Sejuani and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Aftershock is the best keystone rune to run on Sejuani. This keystone rune bulks you up, increasing both armour and magic resistance, once you immobilized a champion. Aftershock synergises both with the sheer amount of crowd control Sejuani possesses and the need to be tanky as soon as you engage. Other primary runes on Sejuani are 
Font of Life, 
Conditioning and 
Overgrowth.
Font of Life provides your teammates with more sustain by healing them whenever they attack a champion whose movement you've recently impaired. Conditioning powers up Sejuani tankiness after the laning phase. Overgrowth increases your maximum amount of health.
Sejuani runes from secondary path
When it comes to your secondary path, most Sejuani players prefer to go with Domination. Domination improves burst damage and assassination tools on Sejuani. On the Domination path, the best runes for Sejuani are 
Ultimate Hunter and 
Sudden Impact.
Ultimate Hunter scales up Sejuani ultimate haste on every unique champion takedown. Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Sejuani with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
FAQ for Sejuani Runes
Which is the best keystone rune on Sejuani?
The best keystone rune on Sejuani is Aftershock. This Sejuani runes setup is then referred as Sejuani Aftershock.
What runes does Sejuani use?
Runes from the paths Resolve and Domination are the most used runes on Sejuani. For the exact pick rates of Sejuani runes used, you have to study the rune distribution presented.