Ryze Runes explained
There's one set of runes for Ryze on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Ryze rune paths on the position 
Mid are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 36%. Besides picking runes on Ryze you should learn how to play Ryze and if you are interested in pro matches take a look on how a pro builds Ryze. If you want to discuss 
Ryze then you should visit the champion subreddit.
Ryze runes from primary path
Sorcery empoweres abilities of Ryze and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Phase Rush is the best keystone rune to run on Ryze. Phase Rush offers more flexibility and options to betake oneself in and out of danger, which can be helpful since that's essentially the main playstyle of Ryze. Other primary runes on Ryze are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Ryze runes from secondary path
When it comes to your secondary path, most Ryze players prefer to go with Inspiration. Inspiration opens creative opportunities on Ryze troughout the match. On the Inspiration path, the best runes for Ryze are Biscuit Delivery and Cosmic Insight.
Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
FAQ for Ryze Runes
Which is the best keystone rune on Ryze?
The best keystone rune on Ryze is Phase Rush. This Ryze runes setup is then referred as Ryze Phase Rush.
What runes does Ryze use?
Runes from the paths Sorcery and Inspiration are the most used runes on Ryze. For the exact pick rates of Ryze runes used, you have to study the rune distribution presented.