Qiyana Runes explained
There's one set of runes for Qiyana on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Qiyana rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 92%. Besides picking runes on Qiyana you should learn how to play Qiyana and if you are interested in pro matches take a look on how a pro builds Qiyana. If you want to discuss 
Qiyana then you should visit the champion subreddit.
Qiyana runes from primary path
Domination improves burst damage and assassination tools on Qiyana. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Qiyana. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Qiyana are 
Sudden Impact, 
Eyeball Collection and 
Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Qiyana with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Qiyana runes from secondary path
When it comes to your secondary path, most Qiyana players prefer to go with Inspiration. Inspiration opens creative opportunities on Qiyana troughout the match. On the Inspiration path, the best runes for Qiyana are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Qiyana to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Qiyana Runes
Which is the best keystone rune on Qiyana?
The best keystone rune on Qiyana is Electrocute. This Qiyana runes setup is then referred as Qiyana Electrocute.
What runes does Qiyana use?
Runes from the paths Domination and Inspiration are the most used runes on Qiyana. For the exact pick rates of Qiyana runes used, you have to study the rune distribution presented.