Qiyana Runes explained
There's one set of runes for Qiyana on patch 14.24 that is the clear favorite for LoL players and pros alike. The best Qiyana rune paths on the position 
Mid are 
Domination as the primary path and 
Precision as the secondary path with a pick rate of 88%. Besides picking runes on Qiyana you should learn how to play Qiyana and if you are interested in pro matches take a look on how a pro builds Qiyana. If you want to discuss 
Qiyana then you should visit the champion subreddit.
Qiyana runes from primary path
Domination improves burst damage and assassination tools on Qiyana. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Qiyana. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Qiyana are 
Sudden Impact, 
Eyeball Collection and 
Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Qiyana with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Qiyana additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Qiyana will gain an additional 70 gold for the first takedown. Qiyana acquires Bounty Hunter Stacks, which Qiyana may use to get more takedowns. This rune's power will grow tremendously, and Qiyana will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Qiyana will get an additional twenty gold.
Qiyana runes from secondary path
When it comes to your secondary path, most Qiyana players prefer to go with Precision. Precision improves attack and sustained damage on Qiyana troughout the match. On the Precision path, the best runes for Qiyana are 
Presence of Mind and 
Last Stand.
Presence of Mind helps Qiyana with the mana problems by restoring missing mana, if a champion is killed. With Last Stand you deal more damage while you are at low health.
FAQ for Qiyana Runes
Which is the best keystone rune on Qiyana?
The best keystone rune on Qiyana is Electrocute. This Qiyana runes setup is then referred as Qiyana Electrocute.
What runes does Qiyana use?
Runes from the paths Domination and Precision are the most used runes on Qiyana. For the exact pick rates of Qiyana runes used, you have to study the rune distribution presented.