Pantheon Runes explained
There's one set of runes for Pantheon on patch 15.1 that is the clear favorite for LoL players and pros alike. The best Pantheon rune paths on the position 
Support are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 53%. Besides picking runes on Pantheon you should learn how to play Pantheon and if you are interested in pro matches take a look on how a pro builds Pantheon. If you want to discuss 
Pantheon then you should visit the champion subreddit.
Pantheon runes from primary path
Precision improves attack and sustained damage on Pantheon troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Press the Attack is the best keystone rune to run on Pantheon. Pantheon has a very easy time activating this rune with basic attacks which synergises well with Press the Attack’s damage increase once activated. Other primary runes on Pantheon are 
Triumph, 
Legend: Alacrity and 
Last Stand.
Triumph restores on Pantheon a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Pantheon. With Last Stand you deal more damage while you are at low health.
Pantheon runes from secondary path
When it comes to your secondary path, most Pantheon players prefer to go with Inspiration. Inspiration opens creative opportunities on Pantheon troughout the match. On the Inspiration path, the best runes for Pantheon are 
Cosmic Insight and 
Hextech Flashtraption.
Cosmic Insight grants summoner spell and item haste. Having an extra way to decrease the distance with the Hextech Flashtraption will make an engage much easier to pull off.
FAQ for Pantheon Runes
Which is the best keystone rune on Pantheon?
The best keystone rune on Pantheon is Press the Attack. This Pantheon runes setup is then referred as Pantheon Press the Attack.
What runes does Pantheon use?
Runes from the paths Precision and Inspiration are the most used runes on Pantheon. For the exact pick rates of Pantheon runes used, you have to study the rune distribution presented.