Pantheon Runes explained
There's one set of runes for Pantheon on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Pantheon rune paths on the position 
Jungle are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 97%. Besides picking runes on Pantheon you should learn how to play Pantheon and if you are interested in pro matches take a look on how a pro builds Pantheon. If you want to discuss 
Pantheon then you should visit the champion subreddit.
Pantheon runes from primary path
Precision improves attack and sustained damage on Pantheon troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Pantheon. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Pantheon deals additional damage and gains life steal. Other primary runes on Pantheon are 
Triumph, 
Legend: Alacrity and 
Coup de Grace.
Triumph restores on Pantheon a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Pantheon. Pantheon deals with Coup de Grace more damage to targets with low health.
Pantheon runes from secondary path
When it comes to your secondary path, most Pantheon players prefer to go with Inspiration. Inspiration opens creative opportunities on Pantheon troughout the match. On the Inspiration path, the best runes for Pantheon are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Pantheon to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Pantheon Runes
Which is the best keystone rune on Pantheon?
The best keystone rune on Pantheon is Conqueror. This Pantheon runes setup is then referred as Pantheon Conqueror.
What runes does Pantheon use?
Runes from the paths Precision and Inspiration are the most used runes on Pantheon. For the exact pick rates of Pantheon runes used, you have to study the rune distribution presented.