Nocturne Runes explained
There's one set of runes for Nocturne on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Nocturne rune paths on the position 
Jungle are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 90%. Besides picking runes on Nocturne you should learn how to play Nocturne and if you are interested in pro matches take a look on how a pro builds Nocturne. If you want to discuss 
Nocturne then you should visit the champion subreddit.
Nocturne runes from primary path
Precision improves attack and sustained damage on Nocturne troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Nocturne. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Nocturne deals additional damage and gains life steal. Other primary runes on Nocturne are 
Triumph, 
Legend: Alacrity and 
Last Stand.
Triumph restores on Nocturne a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Nocturne. With Last Stand you deal more damage while you are at low health.
Nocturne runes from secondary path
When it comes to your secondary path, most Nocturne players prefer to go with Domination. Domination improves burst damage and assassination tools on Nocturne. On the Domination path, the best runes for Nocturne are 
Ultimate Hunter and 
Eyeball Collection.
Ultimate Hunter scales up Nocturne ultimate haste on every unique champion takedown. Eyeball Collection is next up. This grants the user additional damage with every killing they score.
FAQ for Nocturne Runes
Which is the best keystone rune on Nocturne?
The best keystone rune on Nocturne is Conqueror. This Nocturne runes setup is then referred as Nocturne Conqueror.
What runes does Nocturne use?
Runes from the paths Precision and Domination are the most used runes on Nocturne. For the exact pick rates of Nocturne runes used, you have to study the rune distribution presented.