Milio Runes explained
There's one set of runes for Milio on patch 14.24 that is the clear favorite for LoL players and pros alike. The best Milio rune paths on the position 
Support are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 47%. Besides picking runes on Milio you should learn how to play Milio and if you are interested in pro matches take a look on how a pro builds Milio.
Milio runes from primary path
Sorcery empoweres abilities of Milio and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Summon Aery is the best keystone rune to run on 
Milio. This keystone rune adds more poke damage to your abilities. And additionally grants an extra shield, whenever Milio empowers or protects an ally with abilities. Other primary runes on Milio are 
Manaflow Band, 
Transcendence and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Milio runes from secondary path
When it comes to your secondary path, most Milio players prefer to go with Inspiration. Inspiration opens creative opportunities on Milio troughout the match. On the Inspiration path, the best runes for Milio are Magical Footwear and Cosmic Insight.
Magical Footwear allows Milio to focus on those essential core items without the need to spend the additional 300 gold on boots. Cosmic Insight grants summoner spell and item haste.
FAQ for Milio Runes
Which is the best keystone rune on Milio?
The best keystone rune on Milio is Summon Aery. This Milio runes setup is then referred as Milio Summon Aery.
What runes does Milio use?
Runes from the paths Sorcery and Inspiration are the most used runes on Milio. For the exact pick rates of Milio runes used, you have to study the rune distribution presented.