Master Yi Runes explained
There's one set of runes for Master Yi on patch 15.4 that is the clear favorite for LoL players and pros alike. The best Master Yi rune paths on the position 
Jungle are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 58%. Besides picking runes on Master Yi you should learn how to play Master Yi and if you are interested in pro matches take a look on how a pro builds Master Yi. If you want to discuss 
Master Yi then you should visit the champion subreddit.
Master Yi runes from primary path
Precision improves attack and sustained damage on Master Yi troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Master Yi. This keystone rune gives Master Yi a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Master Yi are 
Triumph, 
Legend: Alacrity and 
Cut Down.
Triumph restores on Master Yi a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Master Yi. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
Master Yi runes from secondary path
When it comes to your secondary path, most Master Yi players prefer to go with Domination. Domination improves burst damage and assassination tools on Master Yi. On the Domination path, the best runes for MasterYi are Sudden Impact and Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Master Yi with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Treasure Hunter is the final rune of the Domination path. This rune gives Master Yi additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Master Yi will gain an additional 70 gold for the first takedown. Master Yi acquires Bounty Hunter Stacks, which Master Yi may use to get more takedowns. This rune's power will grow tremendously, and Master Yi will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Master Yi will get an additional twenty gold.
FAQ for Master Yi Runes
Which is the best keystone rune on Master Yi?
The best keystone rune on Master Yi is Lethal Tempo. This Master Yi runes setup is then referred as Master Yi Lethal Tempo.
What runes does Master Yi use?
Runes from the paths Precision and Domination are the most used runes on Master Yi. For the exact pick rates of Master Yi runes used, you have to study the rune distribution presented.