Lee Sin Runes explained
There's one set of runes for Lee Sin on patch 14.22 that is the clear favorite for LoL players and pros alike. The best Lee Sin rune paths on the position 
Jungle are 
Precision as the primary path and 
Inspiration as the secondary path with a pick rate of 97%. Besides picking runes on Lee Sin you should learn how to play Lee Sin and if you are interested in pro matches take a look on how a pro builds Lee Sin. If you want to discuss 
Lee Sin then you should visit the champion subreddit.
Lee Sin runes from primary path
Precision improves attack and sustained damage on Lee Sin troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Lee Sin. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Lee Sin deals additional damage and gains life steal. Other primary runes on Lee Sin are 
Triumph, 
Legend: Alacrity and 
Coup de Grace.
Triumph restores on Lee Sin a part of missing health and award bonus gold, if a champion is killed. Legend: Alacrity grants additional attack speed to Lee Sin. Lee Sin deals with Coup de Grace more damage to targets with low health.
Lee Sin runes from secondary path
When it comes to your secondary path, most Lee Sin players prefer to go with Inspiration. Inspiration opens creative opportunities on Lee Sin troughout the match. On the Inspiration path, the best runes for LeeSin are 
Magical Footwear and 
Cosmic Insight.
Magical Footwear allows Lee Sin to focus on those essential core items without the need to spend the additional 300 gold on boots. Cosmic Insight grants summoner spell and item haste.
FAQ for Lee Sin Runes
Which is the best keystone rune on Lee Sin?
The best keystone rune on Lee Sin is Conqueror. This Lee Sin runes setup is then referred as Lee Sin Conqueror.
What runes does Lee Sin use?
Runes from the paths Precision and Inspiration are the most used runes on Lee Sin. For the exact pick rates of Lee Sin runes used, you have to study the rune distribution presented.