Kassadin Runes explained
There's one set of runes for Kassadin on patch 14.24 that is the clear favorite for LoL players and pros alike. The best Kassadin rune paths on the position 
Mid are 
Domination as the primary path and 
Resolve as the secondary path with a pick rate of 31%. Besides picking runes on Kassadin you should learn how to play Kassadin and if you are interested in pro matches take a look on how a pro builds Kassadin. If you want to discuss 
Kassadin then you should visit the champion subreddit.
Kassadin runes from primary path
Domination improves burst damage and assassination tools on Kassadin. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Kassadin. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Kassadin are 
Taste of Blood, Eyeball Collection and 
Ultimate Hunter.
Taste of Blood heals Kassadin as soon as you damage an opposing champion. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Ultimate Hunter scales up Kassadin ultimate haste on every unique champion takedown.
Kassadin runes from secondary path
When it comes to your secondary path, most Kassadin players prefer to go with Resolve. Resolve empowers the survivability of Kassadin and increases the tankiness. On the Resolve path, the best runes for Kassadin are Second Wind and Overgrowth.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Overgrowth increases your maximum amount of health.
FAQ for Kassadin Runes
Which is the best keystone rune on Kassadin?
The best keystone rune on Kassadin is Electrocute. This Kassadin runes setup is then referred as Kassadin Electrocute.
What runes does Kassadin use?
Runes from the paths Domination and Resolve are the most used runes on Kassadin. For the exact pick rates of Kassadin runes used, you have to study the rune distribution presented.