Brand Runes explained
There's one set of runes for Brand on patch 14.14 that is the clear favorite for LoL players and pros alike. The best Brand rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 34%. Besides picking runes on Brand you should learn how to play Brand and if you are interested in pro matches take a look on how a pro builds Brand. If you want to discuss 
Brand then you should visit the champion subreddit.
Brand runes from primary path
Domination improves burst damage and assassination tools on Brand. Most of high elo players – and our LoL pros in the the major regions – have agreed that Electrocute is the best keystone rune to run on Brand. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Brand are Cheap Shot, Eyeball Collection and Treasure Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Brand. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Brand additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Brand will gain an additional 70 gold for the first takedown. Brand acquires Bounty Hunter Stacks, which Brand may use to get more takedowns. This rune's power will grow tremendously, and Brand will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Brand will get an additional twenty gold.
Brand runes from secondary path
When it comes to your secondary path, most Brand players prefer to go with Inspiration. Inspiration opens creative opportunities on Brand troughout the match. On the Inspiration path, the best runes for Brand are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Brand to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Brand Runes
Which is the best keystone rune on Brand?
The best keystone rune on Brand is Electrocute. This Brand runes setup is then referred as Brand Electrocute.
What runes does Brand use?
Runes from the paths Domination and Inspiration are the most used runes on Brand. For the exact pick rates of Brand runes used, you have to study the rune distribution presented.