Anivia Runes explained
There's one set of runes for Anivia on patch 14.21 that is the clear favorite for LoL players and pros alike. The best Anivia rune paths on the position 
Mid are 
Sorcery as the primary path and 
Precision as the secondary path with a pick rate of 61%. Besides picking runes on Anivia you should learn how to play Anivia and if you are interested in pro matches take a look on how a pro builds Anivia. If you want to discuss 
Anivia then you should visit the champion subreddit.
Anivia runes from primary path
Sorcery empoweres abilities of Anivia and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that Arcane Comet is the best keystone rune to run on Anivia. This keystone rune adds more damage to your abilities and increases your power in the laning phase. Other primary runes on Anivia are Manaflow Band, Transcendence and Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Transcendence for some more Ability Haste. Scorch increases your control in the early game.
Anivia runes from secondary path
When it comes to your secondary path, most Anivia players prefer to go with Precision. Precision improves attack and sustained damage on Anivia troughout the match. On the Precision path, the best runes for Anivia are 
Presence of Mind and 
Cut Down.
Presence of Mind helps Anivia with the mana problems by restoring missing mana, if a champion is killed. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
FAQ for Anivia Runes
Which is the best keystone rune on Anivia?
The best keystone rune on Anivia is Arcane Comet. This Anivia runes setup is then referred as Anivia Arcane Comet.
What runes does Anivia use?
Runes from the paths Sorcery and Precision are the most used runes on Anivia. For the exact pick rates of Anivia runes used, you have to study the rune distribution presented.