Anivia Runes explained
There's one set of runes for Anivia on patch 15.3 that is the clear favorite for LoL players and pros alike. The best Anivia rune paths on the position 
Top are 
Resolve as the primary path and 
Precision as the secondary path with a pick rate of 68%. Besides picking runes on Anivia you should learn how to play Anivia and if you are interested in pro matches take a look on how a pro builds Anivia. If you want to discuss 
Anivia then you should visit the champion subreddit.
Anivia runes from primary path
Resolve empowers the survivability of Anivia and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that Grasp of the Undying is the best keystone rune to run on Anivia. This keystone rune gives Anivia alot of sustain and helps to force your opposing champion out of the lane. Other primary runes on Anivia are Demolish, Bone Plating and Overgrowth.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent. Bone Plating make Anivia overall tankier, by decreasing the amount of poke damage in the early game. Overgrowth increases your maximum amount of health.
Anivia runes from secondary path
When it comes to your secondary path, most Anivia players prefer to go with Precision. Precision improves attack and sustained damage on Anivia troughout the match. On the Precision path, the best runes for Anivia are 
Presence of Mind and 
Cut Down.
Presence of Mind helps Anivia with the mana problems by restoring missing mana, if a champion is killed. If the enemy team consists of multiple tanks, then the rune Cut Down is the best choice.
FAQ for Anivia Runes
Which is the best keystone rune on Anivia?
The best keystone rune on Anivia is Grasp of the Undying. This Anivia runes setup is then referred as Anivia Grasp of the Undying.
What runes does Anivia use?
Runes from the paths Resolve and Precision are the most used runes on Anivia. For the exact pick rates of Anivia runes used, you have to study the rune distribution presented.