Zoe Runes explained
There's one set of runes for Zoe on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Zoe rune paths on the position 
Mid are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 55%. Besides picking runes on Zoe you should learn how to play Zoe and if you are interested in pro matches take a look on how a pro builds Zoe. If you want to discuss 
Zoe then you should visit the champion subreddit.
Zoe runes from primary path
Domination improves burst damage and assassination tools on Zoe. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on Zoe. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Zoe are 
Taste of Blood, 
Eyeball Collection and 
Treasure Hunter.
Taste of Blood heals Zoe as soon as you damage an opposing champion. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Zoe additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Zoe will gain an additional 70 gold for the first takedown. Zoe acquires Bounty Hunter Stacks, which Zoe may use to get more takedowns. This rune's power will grow tremendously, and Zoe will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Zoe will get an additional twenty gold.
Zoe runes from secondary path
When it comes to your secondary path, most Zoe players prefer to go with Inspiration. Inspiration opens creative opportunities on Zoe troughout the match. On the Inspiration path, the best runes for Zoe are Cosmic Insight and Minion Dematerializer.
Cosmic Insight grants summoner spell and item haste. Minion Dematerializer will help you to control the position of the minion wave.
FAQ for Zoe Runes
Which is the best keystone rune on Zoe?
The best keystone rune on Zoe is Electrocute. This Zoe runes setup is then referred as Zoe Electrocute.
What runes does Zoe use?
Runes from the paths Domination and Inspiration are the most used runes on Zoe. For the exact pick rates of Zoe runes used, you have to study the rune distribution presented.