Qiyana Runes explained
There's one set of runes for Qiyana on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Qiyana rune paths on the position 
Mid are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 71%. Besides picking runes on Qiyana you should learn how to play Qiyana and if you are interested in pro matches take a look on how a pro builds Qiyana. If you want to discuss 
Qiyana then you should visit the champion subreddit.
Qiyana runes from primary path
Precision improves attack and sustained damage on Qiyana troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that Conqueror is the best keystone rune to run on Qiyana. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Qiyana deals additional damage and gains life steal. Other primary runes on Qiyana are Presence of Mind, Legend: Alacrity and Last Stand.
Presence of Mind helps Qiyana with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Qiyana. With Last Stand you deal more damage while you are at low health.
Qiyana runes from secondary path
When it comes to your secondary path, most Qiyana players prefer to go with Domination. Domination improves burst damage and assassination tools on Qiyana. On the Domination path, the best runes for Qiyana are 
Sudden Impact and 
Relentless Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Qiyana with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
FAQ for Qiyana Runes
Which is the best keystone rune on Qiyana?
The best keystone rune on Qiyana is Conqueror. This Qiyana runes setup is then referred as Qiyana Conqueror.
What runes does Qiyana use?
Runes from the paths Precision and Domination are the most used runes on Qiyana. For the exact pick rates of Qiyana runes used, you have to study the rune distribution presented.