Pantheon Runes explained
There's one set of runes for Pantheon on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Pantheon rune paths on the position 
Support are 
Precision as the primary path and 
Domination as the secondary path with a pick rate of 78%. Besides picking runes on Pantheon you should learn how to play Pantheon and if you are interested in pro matches take a look on how a pro builds Pantheon. If you want to discuss 
Pantheon then you should visit the champion subreddit.
Pantheon runes from primary path
Precision improves attack and sustained damage on Pantheon troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Pantheon. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Pantheon deals additional damage and gains life steal. Other primary runes on Pantheon are 
Triumph, 
Legend: Tenacity and 
Coup de Grace.
Triumph restores on Pantheon a part of missing health and award bonus gold, if a champion is killed. Pantheon gains extra Tenacity with every additional stage of Legend: Tenacity. Pantheon deals with Coup de Grace more damage to targets with low health.
Pantheon runes from secondary path
When it comes to your secondary path, most Pantheon players prefer to go with Domination. Domination improves burst damage and assassination tools on Pantheon. On the Domination path, the best runes for Pantheon are 
Relentless Hunter and 
Sudden Impact.
Relentless Hunter increases your movement speed out of combat due to every unique champion takedown. Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Pantheon with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier.
FAQ for Pantheon Runes
Which is the best keystone rune on Pantheon?
The best keystone rune on Pantheon is Conqueror. This Pantheon runes setup is then referred as Pantheon Conqueror.
What runes does Pantheon use?
Runes from the paths Precision and Domination are the most used runes on Pantheon. For the exact pick rates of Pantheon runes used, you have to study the rune distribution presented.