Annie Runes explained
There's one set of runes for Annie on patch 14.9 that is the clear favorite for LoL players and pros alike. The best Annie rune paths on the position 
Support are 
Sorcery as the primary path and 
Inspiration as the secondary path with a pick rate of 92%. Besides picking runes on Annie you should learn how to play Annie and if you are interested in pro matches take a look on how a pro builds Annie. If you want to discuss 
Annie then you should visit the champion subreddit.
Annie runes from primary path
Sorcery empoweres abilities of Annie and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Summon Aery is the best keystone rune to run on Annie. This keystone rune adds more poke damage to your abilities. And additionally grants an extra shield, whenever Annie empowers or protects an ally with abilities. Other primary runes on Annie are 
Manaflow Band, 
Celerity and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Celerity boosts all movement speed bonuses to Annie. Scorch increases your control in the early game.
Annie runes from secondary path
When it comes to your secondary path, most Annie players prefer to go with Inspiration. Inspiration opens creative opportunities on Annie troughout the match. On the Inspiration path, the best runes for Annie are 
Cosmic Insight and 
Biscuit Delivery.
Cosmic Insight grants summoner spell and item haste. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Annie Runes
Which is the best keystone rune on Annie?
The best keystone rune on Annie is Summon Aery. This Annie runes setup is then referred as Annie Summon Aery.
What runes does Annie use?
Runes from the paths Sorcery and Inspiration are the most used runes on Annie. For the exact pick rates of Annie runes used, you have to study the rune distribution presented.