Warwick Runes explained
There's one set of runes for Warwick on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Warwick rune paths on the position 
Top are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 100%. Besides picking runes on Warwick you should learn how to play Warwick and if you are interested in pro matches take a look on how a pro builds Warwick. If you want to discuss 
Warwick then you should visit the champion subreddit.
Warwick runes from primary path
Precision improves attack and sustained damage on Warwick troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Lethal Tempo is the best keystone rune to run on Warwick. This keystone rune gives Warwick a great head start in team fights and allows to put out more damage in that time window. Other primary runes on Warwick are 
Presence of Mind, 
Legend: Alacrity and 
Last Stand.
Presence of Mind helps Warwick with the mana problems by restoring missing mana, if a champion is killed. Legend: Alacrity grants additional attack speed to Warwick. With Last Stand you deal more damage while you are at low health.
Warwick runes from secondary path
When it comes to your secondary path, most Warwick players prefer to go with Resolve. Resolve empowers the survivability of Warwick and increases the tankiness. On the Resolve path, the best runes for Warwick are Revitalize and Second Wind.
Revitalize inceases heals and shields you distribute or receive. Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion.
FAQ for Warwick Runes
Which is the best keystone rune on Warwick?
The best keystone rune on Warwick is Lethal Tempo. This Warwick runes setup is then referred as Warwick Lethal Tempo.
What runes does Warwick use?
Runes from the paths Precision and Resolve are the most used runes on Warwick. For the exact pick rates of Warwick runes used, you have to study the rune distribution presented.