Nunu & Willump Runes explained
There's one set of runes for Nunu & Willump on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Nunu & Willump rune paths on the position 
Mid are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 67%. Besides picking runes on Nunu & Willump you should learn how to play Nunu & Willump and if you are interested in pro matches take a look on how a pro builds Nunu & Willump. If you want to discuss 
Nunu & Willump then you should visit the champion subreddit.
Nunu & Willump runes from primary path
Domination improves burst damage and assassination tools on Nunu & Willump. Most of high elo players – and our LoL pros in the the major regions – have agreed that Electrocute is the best keystone rune to run on Nunu & Willump. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on Nunu & Willump are Cheap Shot, Eyeball Collection and Relentless Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Nunu & Willump. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
Nunu & Willump runes from secondary path
When it comes to your secondary path, most Nunu & Willump players prefer to go with Sorcery. Sorcery empoweres abilities of Nunu & Willump and increases the available champion resources. On the Sorcery path, the best runes for Nunu are 
Waterwalking and 
Celerity.
Waterwalking grants movement speed in the river, which helps Nunu & Willump get around the map quicker. The extra damage will also help in those all important dragon and baron fights. Celerity boosts all movement speed bonuses to Nunu & Willump.
FAQ for Nunu & Willump Runes
Which is the best keystone rune on Nunu & Willump?
The best keystone rune on Nunu & Willump is Electrocute. This Nunu & Willump runes setup is then referred as Nunu & Willump Electrocute.
What runes does Nunu & Willump use?
Runes from the paths Domination and Sorcery are the most used runes on Nunu & Willump. For the exact pick rates of Nunu & Willump runes used, you have to study the rune distribution presented.