Nasus Runes explained
There's one set of runes for Nasus on patch 13.24 that is the clear favorite for LoL players and pros alike. The best Nasus rune paths on the position 
Top are 
Precision as the primary path and 
Resolve as the secondary path with a pick rate of 36%. Besides picking runes on Nasus you should learn how to play Nasus and if you are interested in pro matches take a look on how a pro builds Nasus. If you want to discuss 
Nasus then you should visit the champion subreddit.
Nasus runes from primary path
Precision improves attack and sustained damage on Nasus troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that Fleet Footwork is the best keystone rune to run on Nasus. This keystone rune generates you a lot of sustain and increases your survivability against poke champions in lane. Other primary runes on Nasus are Triumph, Legend: Tenacity and Last Stand.
Triumph restores on Nasus a part of missing health and award bonus gold, if a champion is killed. Nasus gains extra Tenacity with every additional stage of Legend: Tenacity. With Last Stand you deal more damage while you are at low health.
Nasus runes from secondary path
When it comes to your secondary path, most Nasus players prefer to go with Resolve. Resolve empowers the survivability of Nasus and increases the tankiness. On the Resolve path, the best runes for Nasus are 
Second Wind and 
Unflinching.
Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Unflinching inceases Nasus tenacity based on your missing health.
FAQ for Nasus Runes
Which is the best keystone rune on Nasus?
The best keystone rune on Nasus is Fleet Footwork. This Nasus runes setup is then referred as Nasus Fleet Footwork.
What runes does Nasus use?
Runes from the paths Precision and Resolve are the most used runes on Nasus. For the exact pick rates of Nasus runes used, you have to study the rune distribution presented.