LeBlanc Runes explained
There's one set of runes for LeBlanc on patch 13.24 that is the clear favorite for LoL players and pros alike. The best LeBlanc rune paths on the position 
Mid are 
Domination as the primary path and 
Sorcery as the secondary path with a pick rate of 68%. Besides picking runes on LeBlanc you should learn how to play LeBlanc and if you are interested in pro matches take a look on how a pro builds LeBlanc. If you want to discuss 
LeBlanc then you should visit the champion subreddit.
LeBlanc runes from primary path
Domination improves burst damage and assassination tools on LeBlanc. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Electrocute is the best keystone rune to run on LeBlanc. This keystone rune provides burst damage, aiding them in nuking down the enemy carries. Other primary runes on LeBlanc are 
Taste of Blood, 
Eyeball Collection and 
Treasure Hunter.
Taste of Blood heals LeBlanc as soon as you damage an opposing champion. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives LeBlanc additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. LeBlanc will gain an additional 70 gold for the first takedown. LeBlanc acquires Bounty Hunter Stacks, which LeBlanc may use to get more takedowns. This rune's power will grow tremendously, and LeBlanc will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, LeBlanc will get an additional twenty gold.
LeBlanc runes from secondary path
When it comes to your secondary path, most LeBlanc players prefer to go with Sorcery. Sorcery empoweres abilities of LeBlanc and increases the available champion resources. On the Sorcery path, the best runes for Leblanc are 
Manaflow Band and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Scorch increases your control in the early game.
FAQ for LeBlanc Runes
Which is the best keystone rune on LeBlanc?
The best keystone rune on LeBlanc is Electrocute. This LeBlanc runes setup is then referred as LeBlanc Electrocute.
What runes does LeBlanc use?
Runes from the paths Domination and Sorcery are the most used runes on LeBlanc. For the exact pick rates of LeBlanc runes used, you have to study the rune distribution presented.